β-Lactam Cross-Allergy Clinical Tool

Drug-to-Drug Cross-Reactivity Check

Select the culprit β-lactam (patient is allergic to) and the proposed alternative drug.

⚠️ Patient is Allergic To (Culprit Drug)

💊 Proposed Alternative Drug

⚕️

Select both drugs above to see cross-reactivity risk assessment

Find Safe Alternatives

Select the drug the patient is allergic to and see all alternatives ranked by cross-reactivity risk.

⚠️ Patient is Allergic To

Complete Cross-Reactivity Matrix

Click any cell to see detailed information. Rows = culprit drug (patient allergic to). Columns = proposed drug.

High Risk — Avoid

Low Risk — Use with caution

Safe — No significant cross-reactivity

Unknown / Insufficient data

Same drug

⚠️ Clinical Disclaimer: This tool is for educational and decision-support purposes only. Cross-reactivity rates in the literature vary by study design and patient population. Always consider the full clinical context, severity of original reaction (IgE-mediated vs. non-IgE), skin testing where available, and local allergy/immunology guidelines. This tool does not replace clinical judgment. References: Macy & Romano (2014), Blumenthal et al. (2018), Joint Task Force on Practice Parameters (2010), BNF / UpToDate.